Do Nootropics Work?

Nootropics do work with continued use. Nootropics are pills or supplements that when used boost the brain and also trigger useful effects to the brain that include better and increased concentration and increased energy levels to the brain.

Nootropics also do not have adverse side effects or any detectable toxicity, and they improve brain’s resistance to chemical and physical injuries. Nootropics are mostly used by students who need to cram for exams, entrepreneurs looking for brilliant ideas to getting rich, or business people who need energy to work throughout the day.

Nootropics are of different types and each type works differently, all aiming at achieving positive brain effects by changing enzymes, hormones or neurotransmitters supplies. To understand the functioning of nootropics, below are the organs in connection to the functioning and how they affect nootropic functioning.

Do Nootropics Work?

Human brain

The human brain is a very complex organ made of about 100 billion neurons, creating trillions of interactions and connections. Nootropics are drugs that positively impact on the brain. Some nootropics will impact on mood, others enhance memory, as well enhance attention and focus.

The first nootropic was piracetam, which optimizes neuron transmission into the corpus callosum, the area that connects the two brain hemispheres. It also increases levels of the neurotransmitter acetylcholine, which plays a big role in brain functioning.

Most nootropics work in line with brain’s chemistry to increase neutron transmitter production as well inhibiting uptake of the neurotransmitter. This results in positive effects to cognition and mood.

Synaptic receptors and neurotransmitters

Neurotransmitters are chemicals responsible for transmitting neurons from one to the other. As for messages received by the neurotransmitters, they bind to specific receptor sites creating a system. Nootropics then focus on those systems to enhance the efficiency to cognitive function and abilities. Some of the systems include:

Cholinergic system

This system relies on acetylcholine, a neurotransmitter affecting cognitive function. This transmitter plays roles in focus, learning, decision making and memory. Cholinergics are then any supplement that raises acetylcholine levels and is found in diets rich in choline such as eggs, kidneys, liver. Some of the supplements include centrophenoxine and Alpha GPC. Another similar supplement are the racetams, which enhance acetylcholine receptor sensitivity.

Glutamatergic system

This system relies on glutamate neurotransmitter, an excitatory transmitter. It aids in brain health, learning and memory. Nootropics rely on this system for their functioning;one example is aniracetam, which reduces glutamate sensitivity in the brain, thus improving brain activity and cognitive functioning.

Serotonergic and dopaminergic system

These respectively rely on serotonin and dopamine. These neurotransmitters paly vital roles in the usage of nootropics. They affect your well-being and mood, and give you a motivated feeling. They impact positively on the brain’s ability to focus and retain memory. Stimulation of dopamine leads to high brain energy levels and improved cognition.

Oxygen and blood flow into the brain

Some nootropics tend to improve blood and oxygen flow to the brain and glucose metabolism;this increases brain energy levels. The increase in oxygen and nutrient contents translates to increased focus and alertness since the two are the core energy sources in the brain.

With increased supply of oxygen and nutrients, you feel less fatigued and with improved cognition. Motivation is impacted to a sense of well-being.

Paramiracetam is effective in increasing energy levels and focus. It also improves glucose metabolism and blood flow, which leads to proper functioning of the brain.

Brain plasticity

In terms of how the brain changes and learns, brain plasticity becomes very vital. Nootropics alter brain synapses which affect brain plasticity.

How well you recall information and memories depends on the linking of the synapses. Once brain plasticity is enhanced, synapses can then properly connect and communicate effectively.

Taking nootropics improves communication between the two brain hemispheres by creating new synapses which then connect the brain hemispheres. Increased memory and learning are results of taking nootropics; thus, brain plasticity is very crucial.


Nootropics, just like other supplements, have side effects. Some of these side effects include headaches, stomach pain, diarrhea or nausea resulting from excessive use of the supplements.

You should avoid taking nootropics in the late evening or when retiring for bed to avoid and insomnia. However, nootropics are beneficial and boost brain functions.

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